Adaptive Immune Responses in a Multiple Sclerosis Patient with Acute Varicella-Zoster Virus Reactivation during Treatment with Fingolimod

Adaptive Immune Responses in a Multiple Sclerosis Patient with Acute Varicella-Zoster Virus Reactivation during Treatment with Fingolimod

Fingolimod, an oral sphingosine 1-phosphate (S1P) receptor modulator, is approved for the treatment of relapsing forms of multiple sclerosis (MS). The interference with S1P signaling leads to retention particularly of chemokine receptor-7 (CCR7) expressing T cells in lymph nodes. The immunological b...

Full description

Bibliographic Details
Main Authors: Andrea Harrer, Peter Wipfler, Georg Pilz, Katrin Oppermann, Elisabeth Haschke-Becher, Shahrzad Afazel, Jörg Kraus, Eugen Trinka, Johann Sellner
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:International Journal of Molecular Sciences
Subjects:
VZV reactivation
fingolimod
treatment discontinuation
immune reconstitution
peripheral blood
cerebrospinal fluid
Online Access:http://www.mdpi.com/1422-0067/16/9/21832

Internet

http://www.mdpi.com/1422-0067/16/9/21832

Similar Items