Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight.

Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status. Mice lacking neuropeptide Y (NPY), a well-known o...

Full description

Bibliographic Details
Main Authors: Paul A Baldock, Nicola J Lee, Frank Driessler, Shu Lin, Susan Allison, Bernhard Stehrer, En-Ju D Lin, Lei Zhang, Ronald F Enriquez, Iris P L Wong, Michelle M McDonald, Matthew During, Dominique D Pierroz, Katy Slack, Yan C Shi, Ernie Yulyaningsih, Aygul Aljanova, David G Little, Serge L Ferrari, Amanda Sainsbury, John A Eisman, Herbert Herzog
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2794533?pdf=render