Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp.

Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp.

Scrub typhus is an important endemic disease in tropical Asia caused by Orientia tsutsugamushi for which no effective broadly protective vaccine is available. The successful evaluation of vaccine candidates requires well-characterized animal models and a better understanding of the immune response a...

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Bibliographic Details
Main Authors: Piyanate Sunyakumthorn, Suwit J Somponpun, Rawiwan Im-Erbsin, Tippawan Anantatat, Kemajittra Jenjaroen, Susanna J Dunachie, Eric D Lombardini, Robin L Burke, Stuart D Blacksell, James W Jones, Carl J Mason, Allen L Richards, Nicholas P J Day, Daniel H Paris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5862536?pdf=render

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http://europepmc.org/articles/PMC5862536?pdf=render

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