Confidence-based somatic mutation evaluation and prioritization.

Confidence-based somatic mutation evaluation and prioritization.

Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms. However, NGS-based somatic mutation detection is prone to erroneous calls, with reported validation rates near 54%...

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Bibliographic Details
Main Authors: Martin Löwer, Bernhard Y Renard, Jos de Graaf, Meike Wagner, Claudia Paret, Christoph Kneip, Ozlem Türeci, Mustafa Diken, Cedrik Britten, Sebastian Kreiter, Michael Koslowski, John C Castle, Ugur Sahin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028300/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028300/?tool=EBI

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