Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways

Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways

Abstract Background Increasing evidence suggests that high glucose (HG) causes abnormalities in endothelial and vascular smooth muscle cell function (VSMC) and contributes to atherosclerosis. Receptor for advanced glycation end-products (RAGE) has been linked to the pathogenesis of both the macrovas...

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Bibliographic Details
Main Authors: Sheng-Chiang Su, Yi-Jen Hung, Chia-Luen Huang, Yi-Shing Shieh, Chu-Yen Chien, Chi-Fu Chiang, Jhih-Syuan Liu, Chieh-Hua Lu, Chang-Hsun Hsieh, Chien-Ming Lin, Chien-Hsing Lee
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Biomedical Science
Subjects:
Cilostazol
Vascular smooth muscle
RAGE
Diabetes
Online Access:http://link.springer.com/article/10.1186/s12929-019-0550-9

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http://link.springer.com/article/10.1186/s12929-019-0550-9

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