Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling

Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling

Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.

Bibliographic Details
Main Authors: Brian D. Robinson, Panagiotis J. Vlachostergios, Bhavneet Bhinder, Weisi Liu, Kailyn Li, Tyler J. Moss, Rohan Bareja, Kyung Park, Peyman Tavassoli, Joanna Cyrta, Scott T. Tagawa, David M. Nanus, Himisha Beltran, Ana M. Molina, Francesca Khani, Juan Miguel Mosquera, Evanguelos Xylinas, Shahrokh F. Shariat, Douglas S. Scherr, Mark A. Rubin, Seth P. Lerner, Surena F. Matin, Olivier Elemento, Bishoy M. Faltas
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10873-y

Internet

https://doi.org/10.1038/s41467-019-10873-y

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