Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts

Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts

Murine studies have linked TGF-β signaling to emphysema, and human genome-wide association studies (GWAS) studies of lung function and COPD have identified associated regions near genes in the TGF-β superfamily. However, the functional regulatory mechanisms at these loci have not been identified. We...

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Bibliographic Details
Main Authors: Margaret M Parker, Yuan Hao, Feng Guo, Betty Pham, Robert Chase, John Platig, Michael H Cho, Craig P Hersh, Victor J Thannickal, James Crapo, George Washko, Scott H Randell, Edwin K Silverman, Raúl San José Estépar, Xiaobo Zhou, Peter J Castaldi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
COPD
genome-wide association study
transcriptomics
TGF-beta signaling
emphysema
bioinformatics
Online Access:https://elifesciences.org/articles/42720

Internet

https://elifesciences.org/articles/42720

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