Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies

Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies

Abstract Antibody-based PD-1/PD-L1 blockade therapies have taken center stage in immunotherapies for cancer, with multiple clinical successes. PD-1 signaling plays pivotal roles in tumor-driven T-cell dysfunction. In contrast to prior approaches to generate or boost tumor-specific T-cell responses,...

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Bibliographic Details
Main Authors: Shuguang Tan, Danqing Chen, Kefang Liu, Mengnan He, Hao Song, Yi Shi, Jun Liu, Catherine W.-H. Zhang, Jianxun Qi, Jinghua Yan, Shan Gao, George F. Gao
Format: Article
Language:English
Published: SpringerOpen 2016-11-01
Series:Protein & Cell
Subjects:
PD-1/PD-L1 interaction
checkpoint blockade
molecular basis
therapeutic antibody
Online Access:http://link.springer.com/article/10.1007/s13238-016-0337-7

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http://link.springer.com/article/10.1007/s13238-016-0337-7

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