The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.

The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signal-transduction pathway is impaired in many cardiovascular diseases, including pulmonary arterial hypertension (PAH). Riociguat (BAY 63-2521) is a stimulator of sGC that works both in synergy with and ind...

Full description

Bibliographic Details
Main Authors: Michaela Lang, Baktybek Kojonazarov, Xia Tian, Anuar Kalymbetov, Norbert Weissmann, Friedrich Grimminger, Axel Kretschmer, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3422306?pdf=render

Internet

http://europepmc.org/articles/PMC3422306?pdf=render

Similar Items