Antigen-specific response of CD4+ T cells and hepatic lymph node cells to Fasciola hepatica-derived molecules at the early and late stage of the infection in sheep

Antigen-specific response of CD4+ T cells and hepatic lymph node cells to Fasciola hepatica-derived molecules at the early and late stage of the infection in sheep

Abstract The immunomodulatory capacity of F. hepatica antigens is probably one of the main reasons for the development of a driven non-protective Th2 immune response. In this study, we analysed the cellular response of hepatic lymph node cells and CD4+ T cells in terms of proliferative response, eff...

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Bibliographic Details
Main Authors: Raúl Pérez-Caballero, F. Javier Martínez-Moreno, Yolanda Corripio-Miyar, Tom N. McNeilly, Krystyna Cwiklinski, John P. Dalton, Rafael Zafra, José Pérez, Álvaro Martínez-Moreno, Leandro Buffoni
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Veterinary Research
Subjects:
Hepatic lymph nodes
CD4+ T cells
cytokines
F. hepatica
sheep
ruminants
Online Access:https://doi.org/10.1186/s13567-021-00963-5

Internet

https://doi.org/10.1186/s13567-021-00963-5

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