Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells

Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells

Abstract Background The diagnosis of glioblastoma (GBM), a most aggressive primary brain tumor with a median survival of 14.6 months, carries a dismal prognosis. GBMs are characterized by numerous genetic and epigenetic alterations, affecting patient survival and treatment response. Epigenetic mecha...

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Bibliographic Details
Main Authors: Halina Was, Sylwia K. Krol, Dante Rotili, Antonello Mai, Bartosz Wojtas, Bozena Kaminska, Marta Maleszewska
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Clinical Epigenetics
Subjects:
Glioblastoma
Histone deacetylase
HDAC inhibitors
Epigenetic drugs
Glioma stem cells
Cell proliferation
Online Access:http://link.springer.com/article/10.1186/s13148-018-0598-5

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http://link.springer.com/article/10.1186/s13148-018-0598-5

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