Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor

Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor

Abstract Background The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carcinoma (MTC)), thus matching with a theranostic principle. Several pepti...

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Bibliographic Details
Main Authors: Piotr F. J. Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz. Dobrowolski, Marta K. Dudek, Monika Orzełowska, Renata Mikołajczak
Format: Article
Language:English
Published: SpringerOpen 2018-04-01
Series:EJNMMI Research
Subjects:
Minigastrin analogue
Medullary thyroid carcinoma
Cholecystokinin receptor subtype 2
Molecular docking
Online Access:http://link.springer.com/article/10.1186/s13550-018-0387-3

Internet

http://link.springer.com/article/10.1186/s13550-018-0387-3

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