Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins

Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins

Abstract The rising prevalence of chronic liver disease, coupled with a permanent shortage of organs for liver transplantation, has sparked enormous interest in alternative treatment strategies. Previous protocols to generate hepatocyte-like cells (HLCs) via pancreas-to-liver transdifferentiation ha...

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Bibliographic Details
Main Authors: Francis D. Gratte, Sara Pasic, John K. Olynyk, George C. T. Yeoh, David Tosh, Deirdre R. Coombe, Janina E. E. Tirnitz-Parker
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-22596-z

Internet

https://doi.org/10.1038/s41598-018-22596-z

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