Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

The essential functions required for mitotic spindle assembly and chromosome biorientation and segregation are not fully understood, despite extensive study. To illuminate the combinations of ingredients most important to align and segregate chromosomes and simultaneously assemble a bipolar spindle,...

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Bibliographic Details
Main Authors: Christopher Edelmaier, Adam R Lamson, Zachary R Gergely, Saad Ansari, Robert Blackwell, J Richard McIntosh, Matthew A Glaser, Meredith D Betterton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/48787