Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV Methods
A comparative study of chemical stability of terfenadine (TER) and its in vivo metabolite fexofenadine (FEX) was performed. Both TER and FEX were subjected to high temperature at different pH and UV/VIS light at different pH and then quantitatively analyzed using new validated LC-UV methods. These m...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2019-01-01
|
Series: | Journal of Analytical Methods in Chemistry |
Online Access: | http://dx.doi.org/10.1155/2019/5790404 |
id |
doaj-1c70da7edab5431e981078bc553db230 |
---|---|
record_format |
Article |
spelling |
doaj-1c70da7edab5431e981078bc553db2302020-11-25T00:52:40ZengHindawi LimitedJournal of Analytical Methods in Chemistry2090-88652090-88732019-01-01201910.1155/2019/57904045790404Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV MethodsAnna Gumieniczek0Anna Berecka-Rycerz1Rafał Pietraś2Izabela Kozak3Karolina Lejwoda4Paweł Kozyra5Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandA comparative study of chemical stability of terfenadine (TER) and its in vivo metabolite fexofenadine (FEX) was performed. Both TER and FEX were subjected to high temperature at different pH and UV/VIS light at different pH and then quantitatively analyzed using new validated LC-UV methods. These methods were used to monitor the degradation processes and to determine the kinetics of degradation for both the compounds. As far as the effects of temperature and pH were concerned, FEX occurred more sensitive to degradation than TER. As far as the effects of UV/VIS light and pH were concerned, the both drugs were similarly sensitive to high doses of light. Using all stress conditions, the processes of degradation of TER and FEX followed the first-order kinetics. The results obtained for these two antihistaminic drugs could be helpful in developing their new derivatives with higher activity and stability at the same time.http://dx.doi.org/10.1155/2019/5790404 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Gumieniczek Anna Berecka-Rycerz Rafał Pietraś Izabela Kozak Karolina Lejwoda Paweł Kozyra |
spellingShingle |
Anna Gumieniczek Anna Berecka-Rycerz Rafał Pietraś Izabela Kozak Karolina Lejwoda Paweł Kozyra Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV Methods Journal of Analytical Methods in Chemistry |
author_facet |
Anna Gumieniczek Anna Berecka-Rycerz Rafał Pietraś Izabela Kozak Karolina Lejwoda Paweł Kozyra |
author_sort |
Anna Gumieniczek |
title |
Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV Methods |
title_short |
Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV Methods |
title_full |
Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV Methods |
title_fullStr |
Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV Methods |
title_full_unstemmed |
Comparative Study of Chemical Stability of Two H1 Antihistaminic Drugs, Terfenadine and Its In Vivo Metabolite Fexofenadine, Using LC-UV Methods |
title_sort |
comparative study of chemical stability of two h1 antihistaminic drugs, terfenadine and its in vivo metabolite fexofenadine, using lc-uv methods |
publisher |
Hindawi Limited |
series |
Journal of Analytical Methods in Chemistry |
issn |
2090-8865 2090-8873 |
publishDate |
2019-01-01 |
description |
A comparative study of chemical stability of terfenadine (TER) and its in vivo metabolite fexofenadine (FEX) was performed. Both TER and FEX were subjected to high temperature at different pH and UV/VIS light at different pH and then quantitatively analyzed using new validated LC-UV methods. These methods were used to monitor the degradation processes and to determine the kinetics of degradation for both the compounds. As far as the effects of temperature and pH were concerned, FEX occurred more sensitive to degradation than TER. As far as the effects of UV/VIS light and pH were concerned, the both drugs were similarly sensitive to high doses of light. Using all stress conditions, the processes of degradation of TER and FEX followed the first-order kinetics. The results obtained for these two antihistaminic drugs could be helpful in developing their new derivatives with higher activity and stability at the same time. |
url |
http://dx.doi.org/10.1155/2019/5790404 |
work_keys_str_mv |
AT annagumieniczek comparativestudyofchemicalstabilityoftwoh1antihistaminicdrugsterfenadineanditsinvivometabolitefexofenadineusinglcuvmethods AT annabereckarycerz comparativestudyofchemicalstabilityoftwoh1antihistaminicdrugsterfenadineanditsinvivometabolitefexofenadineusinglcuvmethods AT rafałpietras comparativestudyofchemicalstabilityoftwoh1antihistaminicdrugsterfenadineanditsinvivometabolitefexofenadineusinglcuvmethods AT izabelakozak comparativestudyofchemicalstabilityoftwoh1antihistaminicdrugsterfenadineanditsinvivometabolitefexofenadineusinglcuvmethods AT karolinalejwoda comparativestudyofchemicalstabilityoftwoh1antihistaminicdrugsterfenadineanditsinvivometabolitefexofenadineusinglcuvmethods AT pawełkozyra comparativestudyofchemicalstabilityoftwoh1antihistaminicdrugsterfenadineanditsinvivometabolitefexofenadineusinglcuvmethods |
_version_ |
1725240979717357568 |