Analgesic Effect of Ziziphus abyssinica Involves Inhibition of Inflammatory Mediators and Modulation of KATP Channels, Opioidergic and Nitrergic Pathways

Analgesic Effect of Ziziphus abyssinica Involves Inhibition of Inflammatory Mediators and Modulation of KATP Channels, Opioidergic and Nitrergic Pathways

The diversity offered by natural products has timelessly positioned them as a good source for novel therapeutics for the management of diverse medical conditions, including pain. This study evaluated hydro-ethanolic root bark extract of Ziziphus abyssinica (ZAE) as well as β-amyrin and polpunonic ac...

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Bibliographic Details
Main Authors: Isaac Tabiri Henneh, Francis Ackah Armah, Elvis Ofori Ameyaw, Robert Peter Biney, Ernest Obese, Eric Boakye-Gyasi, Emmanuel Awintiig Adakudugu, Martins Ekor
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
Ziziphus abyssinica
cytokines
inflammatory pain
anti-nociception
β-amyrin
polpunonic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.714722/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.714722/full

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