An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

Background: Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associated with the pathophysiology of sepsis, but repeat...

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Bibliographic Details
Main Authors: Olga M. Pena, David G. Hancock, Ngan H. Lyle, Adam Linder, James A. Russell, Jianguo Xia, Christopher D. Fjell, John H. Boyd, Robert E.W. Hancock
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:EBioMedicine
Subjects:
Sepsis
Severe sepsis
Diagnosis
Cellular reprogramming
Endotoxin tolerance
Signature
Immune dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641400005X

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http://www.sciencedirect.com/science/article/pii/S235239641400005X

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