Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis.

Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis.

As HIV infected individuals live longer, the prevalence of HIV associated neurocognitive disorders is increasing, despite successful antiretroviral therapy. CD14(+)CD16(+) monocytes are critical to the neuropathogenesis of HIV as they promote viral seeding of the brain and establish neuroinflammatio...

Full description

Bibliographic Details
Main Authors: Dionna W Williams, Tina M Calderon, Lillie Lopez, Loreto Carvallo-Torres, Peter J Gaskill, Eliseo A Eugenin, Susan Morgello, Joan W Berman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23922698/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23922698/?tool=EBI

Similar Items