Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma

Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma

Objective: Pancreatic ductal adenocarcinoma (PDAC) is a disease with high mortality. Many so-called “junk” noncoding RNAs need to be discovered in PDAC. The purpose of this study was therefore to investigate the function and regulatory mechanism of the long noncoding RNA MEG3 in PDAC. Methods: The G...

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Bibliographic Details
Main Authors: Ting Han, Meng Zhuo, Cuncun Yuan, Xiuying Xiao, Jiujie Cui, Guangrong Qin, Liwei Wang, Feng Jiao
Format: Article
Language:English
Published: China Anti-Cancer Association 2020-11-01
Series:Cancer Biology & Medicine
Subjects:
pancreatic ductal adenocarcinoma
meg3
sp1
ezh2
hdac3
mir-374a-5p
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1711

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1711

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