Glucocorticoid effects on the programming of AT1b angiotensin receptor gene methylation and expression in the rat.

Adverse events in pregnancy may 'programme' offspring for the later development of cardiovascular disease and hypertension. Previously, using a rodent model of programmed hypertension we have demonstrated the role of the renin-angiotensin system in this process. More recently we showed tha...

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Bibliographic Details
Main Authors: Irina Bogdarina, Andrea Haase, Simon Langley-Evans, Adrian J L Clark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2821904?pdf=render