Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice.

Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice.

Our previous study showed that besides mRNAs and microRNAs, there are DNA fragments within extracellular vesicles (EVs). The BCR/ABL hybrid gene, involved in the pathogenesis of chronic myeloid leukemia (CML), could be transferred from K562 EVs to neutrophils and decrease their phagocytic activity i...

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Bibliographic Details
Main Authors: Jin Cai, Gengze Wu, Xiaorong Tan, Yu Han, Caiyu Chen, Chuanwei Li, Na Wang, Xue Zou, Xinjian Chen, Faying Zhou, Duofen He, Lin Zhou, Pedro A Jose, Chunyu Zeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4136837?pdf=render

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http://europepmc.org/articles/PMC4136837?pdf=render

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