Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.
Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another a...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-10-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.2005264 |
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doaj-1c8702fa041d44d89c739f6aa96e87792021-07-02T17:07:42ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852018-10-011610e200526410.1371/journal.pbio.2005264Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.Andrew D GreenhalghJuan G ZarrukLuke M HealySam J Baskar JesudasanPriya JhelumChristopher K SalmonAlbert FormanekMatthew V RussoJack P AntelDorian B McGavernBarry W McCollSamuel DavidInfiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another and differentially modulate each other's functions. Importantly, microglia-mediated phagocytosis and inflammation are suppressed by infiltrating macrophages. In the context of spinal cord injury (SCI), preventing such communication increases microglial activation and worsens functional recovery. We suggest that macrophages entering the CNS provide a regulatory mechanism that controls acute and long-term microglia-mediated inflammation, which may drive damage in a variety of CNS conditions.https://doi.org/10.1371/journal.pbio.2005264 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Andrew D Greenhalgh Juan G Zarruk Luke M Healy Sam J Baskar Jesudasan Priya Jhelum Christopher K Salmon Albert Formanek Matthew V Russo Jack P Antel Dorian B McGavern Barry W McColl Samuel David |
| spellingShingle |
Andrew D Greenhalgh Juan G Zarruk Luke M Healy Sam J Baskar Jesudasan Priya Jhelum Christopher K Salmon Albert Formanek Matthew V Russo Jack P Antel Dorian B McGavern Barry W McColl Samuel David Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. PLoS Biology |
| author_facet |
Andrew D Greenhalgh Juan G Zarruk Luke M Healy Sam J Baskar Jesudasan Priya Jhelum Christopher K Salmon Albert Formanek Matthew V Russo Jack P Antel Dorian B McGavern Barry W McColl Samuel David |
| author_sort |
Andrew D Greenhalgh |
| title |
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. |
| title_short |
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. |
| title_full |
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. |
| title_fullStr |
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. |
| title_full_unstemmed |
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. |
| title_sort |
peripherally derived macrophages modulate microglial function to reduce inflammation after cns injury. |
| publisher |
Public Library of Science (PLoS) |
| series |
PLoS Biology |
| issn |
1544-9173 1545-7885 |
| publishDate |
2018-10-01 |
| description |
Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another and differentially modulate each other's functions. Importantly, microglia-mediated phagocytosis and inflammation are suppressed by infiltrating macrophages. In the context of spinal cord injury (SCI), preventing such communication increases microglial activation and worsens functional recovery. We suggest that macrophages entering the CNS provide a regulatory mechanism that controls acute and long-term microglia-mediated inflammation, which may drive damage in a variety of CNS conditions. |
| url |
https://doi.org/10.1371/journal.pbio.2005264 |
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