Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response

Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response

Although the interferon (IFN) signaling pathway is a key host mechanism to restrict infection of a diverse range of viral pathogens, its unrestrained activity either at baseline or in the context of an immune response can result in host cell damage and injury. Here, we used a genome-wide CRISPR-Cas9...

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Bibliographic Details
Main Authors: Hongming Ma, Wei Qian, Monika Bambouskova, Patrick L. Collins, Sofia I. Porter, Andrea K. Byrum, Rong Zhang, Maxim Artyomov, Eugene M. Oltz, Nima Mosammaparast, Jonathan J. Miner, Michael S. Diamond
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
interferon-stimulated gene
regulation
innate immunity
crispr
dna virus
rna virus
antiviral
interferon
Online Access:https://doi.org/10.1128/mBio.00136-20

Internet

https://doi.org/10.1128/mBio.00136-20

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