Unmasking features of the auto‐epitope essential for β1‐adrenoceptor activation by autoantibodies in chronic heart failure

Unmasking features of the auto‐epitope essential for β1‐adrenoceptor activation by autoantibodies in chronic heart failure

Abstract Aims Chronic heart failure (CHF) can be caused by autoantibodies stimulating the heart via binding to first and/or second extracellular loops of cardiac β1‐adrenoceptors. Allosteric receptor activation depends on conformational features of the autoantibody binding site. Elucidating these fe...

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Bibliographic Details
Main Authors: Angela Wölfel, Mathias Sättele, Christina Zechmeister, Viacheslav O. Nikolaev, Martin J. Lohse, Fritz Boege, Roland Jahns, Valérie Boivin‐Jahns
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:ESC Heart Failure
Subjects:
Antibody/autoantibody
β1‐adrenoceptor/β1‐adrenergic receptor
Chronic heart failure
Conformational auto‐epitope
Cyclic peptides/cyclopeptides
Cyclopeptide therapy
Online Access:https://doi.org/10.1002/ehf2.12747

Internet

https://doi.org/10.1002/ehf2.12747

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