Transmembrane-4 L-six family member-1 (TM4SF1) promotes non-small cell lung cancer proliferation, invasion and chemo-resistance through regulating the DDR1/Akt/ERK-mTOR axis

Transmembrane-4 L-six family member-1 (TM4SF1) promotes non-small cell lung cancer proliferation, invasion and chemo-resistance through regulating the DDR1/Akt/ERK-mTOR axis

Abstract Background Tumor chemo-resistance is a hallmark of malignant tumors as well as the major cause of poor survival rates in lung cancer. Transmembrane-4 L-six family member-1 (TM4SF1), an antigen that serves as an oncogene, mainly affects tumor invasion and metastasis. We investigated the role...

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Bibliographic Details
Main Authors: Lin Ye, Chunyun Pu, Jun Tang, Yan Wang, Can Wang, Zhu Qiu, Tingxiu Xiang, Yunmei Zhang, Weiyan Peng
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Respiratory Research
Subjects:
Non-small-cell lung cancer
TM4SF1
Invasion
Migration
Apoptosis
Cell cycle
Online Access:http://link.springer.com/article/10.1186/s12931-019-1071-5

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http://link.springer.com/article/10.1186/s12931-019-1071-5

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