Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

The organic anion transporter Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the blood–brain barrier to the periphery, and t...

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Bibliographic Details
Main Authors: Wayne M. Jepsen, Matthew De Both, Ashley L. Siniard, Keri Ramsey, Ignazio S. Piras, Marcus Naymik, Adrienne Henderson, Matthew J. Huentelman
Format: Article
Language:English
Published: The Company of Biologists 2021-01-01
Series:Biology Open
Subjects:
abcc1
app
amyloid
alzheimer's disease
timp3
cd38
Online Access:http://bio.biologists.org/content/10/1/bio054627

Internet

http://bio.biologists.org/content/10/1/bio054627

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