CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation

CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation

Abstract Background The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodomains and most of them remain unexplored. Results We report that the bro...

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Bibliographic Details
Main Authors: Veronica Garcia-Carpizo, Sergio Ruiz-Llorente, Jacinto Sarmentero, Osvaldo Graña-Castro, David G. Pisano, Maria J. Barrero
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Epigenetics & Chromatin
Subjects:
Epigenetics
Bromodomains
Proliferation
Cancer
Online Access:http://link.springer.com/article/10.1186/s13072-018-0197-x

Internet

http://link.springer.com/article/10.1186/s13072-018-0197-x

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