Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients[S]

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients[S]

A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central role in...

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Bibliographic Details
Main Authors: Michelle Janssens, Jeroen van Smeden, Gert S. Gooris, Wim Bras, Guiseppe Portale, Peter J. Caspers, Rob J. Vreeken, Thomas Hankemeier, Sanja Kezic, Ron Wolterbeek, Adriana P. Lavrijsen, Joke A. Bouwstra
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Journal of Lipid Research
Subjects:
ceramide composition
lamellar phase
lateral packing
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418103

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520418103

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