Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia

Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia

Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no de...

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Bibliographic Details
Main Authors: Vanessa G. Fraga, Henrique C. Guimarães, Antônio L. Teixeira, Maira T. Barbosa, Elvis C. C. Mateo, Maria G. Carvalho, Paulo Caramelli, Karina B. Gomes
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO) 2015-11-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
IL-6
polimorfismo
comprometimento cognitivo não demência
cognição
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015001100899&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015001100899&lng=en&tlng=en

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