Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

Multivalent presentation of viral glycoproteins can substantially increase the elicitation of antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed self-assembling protein nanoparticles with geometries tailored to present the ectodomains of influenza, HIV, and R...

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Bibliographic Details
Main Authors: George Ueda, Aleksandar Antanasijevic, Jorge A Fallas, William Sheffler, Jeffrey Copps, Daniel Ellis, Geoffrey B Hutchinson, Adam Moyer, Anila Yasmeen, Yaroslav Tsybovsky, Young-Jun Park, Matthew J Bick, Banumathi Sankaran, Rebecca A Gillespie, Philip JM Brouwer, Peter H Zwart, David Veesler, Masaru Kanekiyo, Barney S Graham, Rogier W Sanders, John P Moore, Per Johan Klasse, Andrew B Ward, Neil P King, David Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
B lymphocytes
BL21
Lemo21
HEK293F
Online Access:https://elifesciences.org/articles/57659

Internet

https://elifesciences.org/articles/57659

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