Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative diseases

Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative diseases

Abstract Background The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphic alleles: ε2, ε3, and ε4 that give rise to amino acid substitutions. APOE-ε4 is a strong risk factor of sporadic Alzheimer’s disease (AD) but the reason why is still unknown despite intense r...

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Bibliographic Details
Main Authors: K. Minta, G. Brinkmalm, S. Janelidze, S. Sjödin, E. Portelius, E. Stomrud, H. Zetterberg, K. Blennow, O. Hansson, U. Andreasson
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Apolipoprotein E
Cerebrospinal fluid
Mass spectrometry
Online Access:https://doi.org/10.1186/s13195-020-00585-7

Internet

https://doi.org/10.1186/s13195-020-00585-7

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