Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

Long-term delivery of anti-HIV monoclonal antibodies using adeno-associated virus (AAV) holds promise for the prevention and treatment of HIV infection. We previously reported that after receiving a single administration of AAV vector coding for anti-SIV antibody 5L7, monkey 84-05 achieved high leve...

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Bibliographic Details
Main Authors: José M. Martinez-Navio, Sebastian P. Fuchs, Desiree E. Mendes, Eva G. Rakasz, Guangping Gao, Jeffrey D. Lifson, Ronald C. Desrosiers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
gene therapy
AAV vector
long-term expression
broadly neutralizing antibodies
HIV/SIV cure
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00449/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00449/full

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