SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation

SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation

Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII). EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and therefore, EnhII/Cp is essential for the regulation of...

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Bibliographic Details
Main Authors: Hua Yang, Jiayin Mo, Qi Xiang, Peiyi Zhao, Yunting Song, Ge Yang, Kailang Wu, Yingle Liu, Weiyong Liu, Jianguo Wu
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Viruses
Subjects:
hbv core promoter
cp
hbv enhancer ii
enhii
hepatitis b virus
hbv
sex determining region y box2
sox2
viral replication
Online Access:https://www.mdpi.com/1999-4915/12/3/273

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https://www.mdpi.com/1999-4915/12/3/273

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