Sodium valproate promotes the apoptosis of SH-SY5Y cells by activating miR-148a-3p/Mcl-1 signaling pathway

Sodium valproate promotes the apoptosis of SH-SY5Y cells by activating miR-148a-3p/Mcl-1 signaling pathway

Objective To investigate the apoptosis-inducing effect of sodium valproate (VPA) on nerve cells and the underlying mechanism. Methods Human neuroblastoma SH-SY5Y cells treated with VPA of difterent doses were examined for apoptosis and Mcl-1 protein expression using flow cytometry and Western blotti...

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Bibliographic Details
Main Authors: DAI Xufang, YAN Xiaojing, XIE Peng, LIAN Jiqin
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2020-06-01
Series:Di-san junyi daxue xuebao
Subjects:
sodium valproate
sh-sy5y cells
mcl-1
mir-148a-3p
apoptosis
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/202001055.htm

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http://aammt.tmmu.edu.cn/Upload/rhtml/202001055.htm

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