Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients

Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients

Background: Following myocardial infarction, mitral regurgitation (MR) is a common complication. Previous animal studies demonstrated the association of endothelial-to-mesenchymal transition (EndMT) with mitral valve (MV) remodeling. Nevertheless, little is known about how MV tissue responds to isch...

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Bibliographic Details
Main Authors: Adrien Lupieri, Yasufumi Nagata, Livia S. A. Passos, Dakota Beker-Greene, Katherine A. Kirkwood, Jill Wylie-Sears, Zahra Alvandi, Hideyuki Higashi, Judy W. Hung, Sasha A. Singh, Joyce Bischoff, Robert A. Levine, Elena Aikawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ischemic mitral regurgitation
mitral valve
endothelial-to-mesenchymal transition
proteomics
echocardiography
histo-cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.688396/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.688396/full

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