Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and formation of microtubule bundles are understudied. Her...

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Bibliographic Details
Main Authors: Amayra Hernández-Vega, Marcus Braun, Lara Scharrel, Marcus Jahnel, Susanne Wegmann, Bradley T. Hyman, Simon Alberti, Stefan Diez, Anthony A. Hyman
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
tau
phase separation
liquid-like
drops
cytoskeleton
intrinsically disordered proteins
multivalency
tubulin
nucleation
microtubule bundles
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731149X

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http://www.sciencedirect.com/science/article/pii/S221112471731149X

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