The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.

The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.

The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. Here we provide evidence that the E3 ubiquitin ligase Cullin...

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Bibliographic Details
Main Authors: Asif A Dar, Keisuke Sawada, Joseph M Dybas, Emily K Moser, Emma L Lewis, Eddie Park, Hossein Fazelinia, Lynn A Spruce, Hua Ding, Steven H Seeholzer, Paula M Oliver
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001041

Internet

https://doi.org/10.1371/journal.pbio.3001041

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