Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na+/K+-ATPase Profibrotic Signaling Pathways

Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na+/K+-ATPase Profibrotic Signaling Pathways

Cardiotonic steroids (CTS) are Na+/K+-ATPase (NKA) ligands that are elevated in volume-expanded states and associated with cardiac and renal dysfunction in both clinical and experimental settings. We test the hypothesis that the CTS telocinobufagin (TCB) promotes renal dysfunction in a process invol...

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Bibliographic Details
Main Authors: David J. Kennedy, Fatimah K. Khalaf, Brendan Sheehy, Malory E. Weber, Brendan Agatisa-Boyle, Julijana Conic, Kayla Hauser, Charles M. Medert, Kristen Westfall, Philip Bucur, Olga V. Fedorova, Alexei Y. Bagrov, W. H. Wilson Tang
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
telocinobufagin
cardiotonic steroids
Na+/K+-ATPase
kidney
fibrosis
signaling
Online Access:http://www.mdpi.com/1422-0067/19/9/2566

Internet

http://www.mdpi.com/1422-0067/19/9/2566

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