Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds

Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds

Human pluripotent stem cell derived neurons have the potential for cell replacement therapy for brain injury and disease but problems on transplantation need to be overcome. Here, the authors use a microtopographic scaffold to graft neurons into both hippocampal organoids and the mouse brain striatu...

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Bibliographic Details
Main Authors: Aaron L. Carlson, Neal K. Bennett, Nicola L. Francis, Apoorva Halikere, Stephen Clarke, Jennifer C. Moore, Ronald P. Hart, Kenneth Paradiso, Marius Wernig, Joachim Kohn, Zhiping P. Pang, Prabhas V. Moghe
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10862

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https://doi.org/10.1038/ncomms10862

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