DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II

DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II

DNA double strand breaks (DSBs) are the most cytotoxic lesions of those occurring in the DNA and can lead to cell death or result in genome mutagenesis and chromosomal translocations. Although most of these rearrangements have detrimental effects for cellular survival, single events can provide clon...

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Bibliographic Details
Main Author: Fernando Gómez-Herreros
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
DSB repair
DNA topoisomerase II
chromosomal translocations
genome instability
transcription
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00141/full

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https://www.frontiersin.org/article/10.3389/fmolb.2019.00141/full

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