Muscone derivative ZM-32 inhibits breast tumor angiogenesis by suppressing HuR-mediated VEGF and MMP9 expression

Muscone derivative ZM-32 inhibits breast tumor angiogenesis by suppressing HuR-mediated VEGF and MMP9 expression

Inhibition of tumor angiogenesis is a highly effective strategy for cancer treatment. Human antigen R (HuR), an RNA-binding protein, is overexpressed in many cancers and regulates the mRNAs of multiple angiogenic factors by binding to the adenylate-uridylate-rich element in their 3′ untranslated reg...

Full description

Bibliographic Details
Main Authors: Liu-qing Yang, Shao-peng Yu, Yan-tao Yang, Yi-shuang Zhao, Fei-yun Wang, Yao Chen, Qing-hua Li, Ping Tian, Yu-ying Zhu, Jian-ge Zhang, Guo-qiang Lin
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Muscone derivatives
Angiogenesis
Macrophage
HuR
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221000500

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221000500

Similar Items