Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.

Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.

Current antidepressant treatments are inadequate for many individuals, and when they are effective, they require several weeks of administration before a therapeutic effect can be observed. Improving the treatment of depression is challenging. Recently, the two-pore domain potassium channel TREK-1 h...

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Bibliographic Details
Main Authors: Jean Mazella, Olivier Pétrault, Guillaume Lucas, Emmanuel Deval, Sophie Béraud-Dufour, Carine Gandin, Malika El-Yacoubi, Catherine Widmann, Alice Guyon, Eric Chevet, Said Taouji, Grégory Conductier, Alain Corinus, Thierry Coppola, Gabriella Gobbi, Jean-Louis Nahon, Catherine Heurteaux, Marc Borsotto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20405001/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20405001/pdf/?tool=EBI

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