Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12

Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12

Mutations in presenilin-1 (PS1) can cause early onset familial Alzheimer's disease (AD). Studies of cultured cells and mice expressing mutant PS1 suggest that PS1 mutations may promote neuronal dysfunction and degeneration by altering cellular calcium homeostasis. On the other hand, it has been...

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Bibliographic Details
Main Authors: Sic L. Chan, Carsten Culmsee, Norman Haughey, Wolfram Klapper, Mark P. Mattson
Format: Article
Language:English
Published: Elsevier 2002-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
endoplasmic reticulum
hippocampal neurons
PARP
topoisomerase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905425

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http://www.sciencedirect.com/science/article/pii/S0969996102905425

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