Evaluation of some aspects in supervised cell type identification for single-cell RNA-seq: classifier, feature selection, and reference construction

Abstract Background Cell type identification is one of the most important questions in single-cell RNA sequencing (scRNA-seq) data analysis. With the accumulation of public scRNA-seq data, supervised cell type identification methods have gained increasing popularity due to better accuracy, robustnes...

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Bibliographic Details
Main Authors: Wenjing Ma, Kenong Su, Hao Wu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-021-02480-2