Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.

Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). However, the cellular and genetic mechanisms at work in pathological TDP-43 toxicity are not fully elucidated. To identify ge...

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Bibliographic Details
Main Authors: Nicole F Liachko, Aleen D Saxton, Pamela J McMillan, Timothy J Strovas, C Dirk Keene, Thomas D Bird, Brian C Kraemer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008526

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https://doi.org/10.1371/journal.pgen.1008526

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