Engineering of Aeromonas caviae Polyhydroxyalkanoate Synthase Through Site-Directed Mutagenesis for Enhanced Polymerization of the 3-Hydroxyhexanoate Unit

Engineering of Aeromonas caviae Polyhydroxyalkanoate Synthase Through Site-Directed Mutagenesis for Enhanced Polymerization of the 3-Hydroxyhexanoate Unit

Polyhydroxyalkanoate (PHA) synthase is an enzyme that polymerizes the acyl group of hydroxyacyl-coenzyme A (CoA) substrates. Aeromonas caviae PHA synthase (PhaCAc) is an important biocatalyst for the synthesis of a useful PHA copolymer, poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] [P(3HB-co...

Full description

Bibliographic Details
Main Authors: Ken Harada, Shingo Kobayashi, Kanji Oshima, Shinichi Yoshida, Takeharu Tsuge, Shunsuke Sato
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
polyhydroxyalkanoate
PHA synthase
copolymer composition
site-directed mutagenesis
homology modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.627082/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.627082/full

Similar Items