RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3

RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3

Abstract The most common genetic cause of amyotrophic lateral sclerosis (ALS) is a GGGGCC (G4C2) hexanucleotide repeat expansions in first intron of the C9orf72 gene. The accumulation of repetitive RNA sequences can mediate toxicity potentially through the formation of intranuclear RNA foci that seq...

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Main Authors: Nandini Ramesh, Elizabeth L. Daley, Amanda M. Gleixner, Jacob R. Mann, Sukhleen Kour, Darilang Mawrie, Eric N. Anderson, Julia Kofler, Christopher J. Donnelly, Evangelos Kiskinis, Udai Bhan Pandey
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Acta Neuropathologica Communications
Online Access:http://link.springer.com/article/10.1186/s40478-020-01060-y

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http://link.springer.com/article/10.1186/s40478-020-01060-y

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