Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

Abstract The transcription factor erythroid 2-related factor 2 (Nrf2) and brain-derived neurotrophic factor (BDNF) play a key role in depression. However, the molecular mechanisms underlying the crosstalk between Nrf2 and BDNF in depression remain unclear. We examined whether Nrf2 regulates the tran...

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Bibliographic Details
Main Authors: Wei Yao, Song Lin, Jin Su, Qianqian Cao, Yueyue Chen, Jiaxu Chen, Zhentao Zhang, Kenji Hashimoto, Qi Qi, Ji-chun Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01261-6

Internet

https://doi.org/10.1038/s41398-021-01261-6

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