A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study

A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study

BackgroundVitamin K antagonists (VKA) are used as prophylaxis for thromboembolic events in patients with cardiovascular diseases. The most common VKA are warfarin and acenocoumarol. These drugs have a narrow therapeutic margin and high inter-individual response variability due to clinical and pharma...

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Bibliographic Details
Main Authors: Angela Roco, Elena Nieto, Marcelo Suárez, Mario Rojo, Maria Paz Bertoglia, Gabriel Verón, Francisca Tamayo, Annabella Arredondo, Daniela Cruz, Jessica Muñoz, Gabriela Bravo, Patricio Salas, Fanny Mejías, Gerald Godoy, Paulo Véliz, Luis Abel Quiñones
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
acenocoumarol
coumarins
algorithm
pharmacogenetics
pharmacogenomics
anticoagulation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00325/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00325/full

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