CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes andphenytoin adverse reactions correlation

OBJECTIVE: CYP2C9 is a major enzyme in human drug metabolism and the polymorphism observed in the corresponding gene may affect therapeutic outcome during treatment. The distribution of variant CYP2C9 alleles and prevalence of phenytoin adverse reactions were hereby investigated in a population of p...

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Bibliographic Details
Main Authors: Carlos Alexandre Twardowschy, Lineu César Werneck, Rosana Herminia Scola, Luciano De Paola, Carlos Eduardo Silvado
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO) 2011-04-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000200002&lng=en&tlng=en